Synthesis of Novel N- and C-acyclic Nucleosides Derived from 2-hydrazino-6-methyluracil | ||
| Egyptian Journal of Chemistry | ||
| Article 29, Volume 63, Issue 7, July 2020, Pages 2775-2781 PDF (1.34 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2020.21459.2279 | ||
| Authors | ||
| Hayam A. Abd El Salam1; A.M. Gaafar* 2 | ||
| 1Green Chemistry Department, National Research Centre, 33 EL Bohouthst. (former EL Tahrirst.) – Dokki – Giza – Egypt - P.O.12622. | ||
| 2Department of Photochemistry,National Research Centre, 33 EL Bohouthst. (former EL Tahrirst.) – Dokki – Giza – Egypt - P.O.12622 | ||
| Abstract | ||
| The reaction of 2-hydrazino-6-methyl uracil with different aldo- sugars yields the corresponding N-acyclic glycosides. However, some of them have cyclized successfully to form a new fused triazole ring. Apparently, such cyclization depends upon the Stereochemistry of the N-glycoside intermediates that produce the C-glycosides.” | ||
| Keywords | ||
| Uracil; N-glycoside; C-glycoside; acyclic nucleoside | ||
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