Synthesis, Molecular Modeling and Biological Evaluation of Indeno[1,2-b]quinoxaline Derivatives as Antifungal and Antibacterial Agents | ||||
Egyptian Journal of Chemistry | ||||
Article 14, Volume 63, Issue 7, July 2020, Page 2577-2590 PDF (1.7 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2020.21366.2275 | ||||
View on SCiNiTO | ||||
Authors | ||||
Hayam A. Abd El salam 1; Magda A. El-Bendary2; Medhat Ibrahim3; Fatma A. El-Samahy 1 | ||||
1Green Chemistry Department, Chemical Industrial Research Division, National Research Centre. | ||||
2Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre. | ||||
3Spectroscopy Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza, Egypt, P.O.12622. | ||||
Abstract | ||||
The (11H-indeno[1,2-b]quinoxalin-11-ylidene)thiocarbohydrazonewere synthesized and consequently some new novel structures were obtained in a good yields. Their chemical structures were assigned by means of spectral analysis. Molecular modeling at B3LYP/6-31 g (d, p) is utilized to calculate both the optimized structure and vibrational spectra of some studied structures. A promising antimicrobial result was obtained from the new synthesized compounds. | ||||
Keywords | ||||
11Н-Indeno [1; 2-b]quinoxalin-2-one; Thiocarbohydrazides; 2- Chloroacetamide derivatives; Molecular modeling; antimicrobial activity | ||||
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