New Acetyl Triterpenoidal and Biological Activities of Euphorbia Paralias and Euophorbia Geniculata (Euphorbiaceae) from Egypt
Ghani, A., eltomy, S., eldougdoug, W., Badr, W., hassan, H. (2020). New Acetyl Triterpenoidal and Biological Activities of Euphorbia Paralias and Euophorbia Geniculata (Euphorbiaceae) from Egypt. EKB Journal Management System, 63(10), 3583-3595. doi: 10.21608/ejchem.2020.20211.2215
Afaf Ghani; sayed eltomy; Wagdi eldougdoug; Wafaa Badr; hanaa hassan. "New Acetyl Triterpenoidal and Biological Activities of Euphorbia Paralias and Euophorbia Geniculata (Euphorbiaceae) from Egypt". EKB Journal Management System, 63, 10, 2020, 3583-3595. doi: 10.21608/ejchem.2020.20211.2215
Ghani, A., eltomy, S., eldougdoug, W., Badr, W., hassan, H. (2020). 'New Acetyl Triterpenoidal and Biological Activities of Euphorbia Paralias and Euophorbia Geniculata (Euphorbiaceae) from Egypt', EKB Journal Management System, 63(10), pp. 3583-3595. doi: 10.21608/ejchem.2020.20211.2215
Ghani, A., eltomy, S., eldougdoug, W., Badr, W., hassan, H. New Acetyl Triterpenoidal and Biological Activities of Euphorbia Paralias and Euophorbia Geniculata (Euphorbiaceae) from Egypt. EKB Journal Management System, 2020; 63(10): 3583-3595. doi: 10.21608/ejchem.2020.20211.2215

New Acetyl Triterpenoidal and Biological Activities of Euphorbia Paralias and Euophorbia Geniculata (Euphorbiaceae) from Egypt

Egyptian Journal of Chemistry
Article 1, Volume 63, Issue 10, October 2020, Page 3583-3595  XML PDF (1.35 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.20211.2215
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Authors
Afaf Ghani1; sayed eltomyorcid 2; Wagdi eldougdoug3; Wafaa Badr3; hanaa hassan email 4
1Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University.
2Chemistry of Tannins Department, National Research Centre, Dokki, Cairo, Egypt
3Department of Organic Chemistry, Faculty of Science, Banha University,
4Pharmacy Department Banha Educational Hospital.
Abstract
Abstract: Phytochemical study of the aerial parts of Euphorbia paralias and Euophorbia geniculata belonging to family (Euophorbiaceae) grown in Egypt was carried out. This study revealed the isolation of eighteen compounds: β-amyrin (1), β-sitosterol and Stigmasterol mixture (2 & 3), Cholesterol (4), Campesterol (5), (Erythradiol, Ovaol and Betulinol mixture)( 6-8), 23-acetyl-3- methyl-oleanolic acid (9) and β-Sitosterol–3-O-glucoside (10) were isolated from dichloromethane fraction of E. paralias. While the compounds 1 to 5 and 10 were isolated from E. geniculata. The ethyl acetate fraction of E. paralias L. afforded the isolation of Gallic acid (11), Ellagic acid (12), Querecetin-3-glucopyranoside (13) and Querecetin -3-arabinoside (14), kaempferol-3-(6''-(2'''-galloyl-glucopyranoside) (15). While compounds 11 to 14 in addition to Querecetin-3-rutinoside (rutin) (16), Querecetin-3-rhamnoside (17), and Querecetin (18) were isolated from E. geniculata Ortega. Compound 9 (23-acetyl-3-methyl-oleanolic acid) was isolated for the first time from the nature. Biological activities were carried out including cytotoxic and antiviral and antimicrobial activities of the dichloromethane and ethyl acetate fractions of the aerial parts of E. paralias L. and E. geniculata Ortega revealing significant antimicrobial activity of ethyl acetate fractions of E. paralias L. and E. geniculata Ortega and strong cytotoxic activity of the ethyl acetate fractions in addition to positive antiviral activity of the total extract of E. paralias L.
Keywords
Triterpenes; Flavonoids; Phenolics; cytotoxic; antimicrobial and antiviral
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