Early Diagnosis and Treatment of N-Methyl D-Aspartate Receptor Autoimmune Encephalitis in Children
Ali Nassr, A., El-Behedy, R., Zidan, H., Mohammed, A. (2022). Early Diagnosis and Treatment of N-Methyl D-Aspartate Receptor Autoimmune Encephalitis in Children. EKB Journal Management System, 28(6.2), 185-191. doi: 10.21608/zumj.2020.19386.1618
Ali Faraj Ali Nassr; Rabab Mohammed El-Behedy; Haidy Essam Zidan; Ahmed Hosny Mohammed. "Early Diagnosis and Treatment of N-Methyl D-Aspartate Receptor Autoimmune Encephalitis in Children". EKB Journal Management System, 28, 6.2, 2022, 185-191. doi: 10.21608/zumj.2020.19386.1618
Ali Nassr, A., El-Behedy, R., Zidan, H., Mohammed, A. (2022). 'Early Diagnosis and Treatment of N-Methyl D-Aspartate Receptor Autoimmune Encephalitis in Children', EKB Journal Management System, 28(6.2), pp. 185-191. doi: 10.21608/zumj.2020.19386.1618
Ali Nassr, A., El-Behedy, R., Zidan, H., Mohammed, A. Early Diagnosis and Treatment of N-Methyl D-Aspartate Receptor Autoimmune Encephalitis in Children. EKB Journal Management System, 2022; 28(6.2): 185-191. doi: 10.21608/zumj.2020.19386.1618

Early Diagnosis and Treatment of N-Methyl D-Aspartate Receptor Autoimmune Encephalitis in Children

Zagazig University Medical Journal
Article 27, Volume 28, Issue 6.2, November 2022, Page 185-191  XML PDF (242.81 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.19386.1618
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Authors
Ali Faraj Ali Nassr email 1; Rabab Mohammed El-Behedy2; Haidy Essam Zidan3; Ahmed Hosny Mohammed4
1M.B.B.Ch., Department of Pediatrics, Faculty of Medicine, Aljabal Algharbi University, Libya
2Professor of Pediatrics, Faculty of Medicine Zagazig University
3Assistant Professor of Biochemistry, Faculty of Medicine Zagazig University
4Lecturer of Pediatrics, Faculty of Medicine Zagazig University
Abstract
Background: Acute pediatric encephalitis is a debilitating neurological disorder that develops as a rapidly progressive encephalopathy (usually in less than 6 weeks) due to brain inflammation, autoimmune encephalitis (AE) is a heterogeneous group of recently identified disorders. Despite severe and even prolonged neurologic deficits, dramatic improvements may occur with proper immunotherapy in some patients with AE. Anti-neuronal antibodies have been discovered in cerebrospinal fluid (CSF) of patients, Aim and Objectives: The aim of the current study was to test the relation of early diagnosis with treatment of N-methyl D- Aspartate Receptor autoimmune encephalitis. Patients and Methods: This is Prospective observational cohort study that was carried out at pediatric department, Faculty of Medicine, Zagazig University, the study was conducted on 36 cases, Results: There was no statistical significant difference between the studied groups with and without autoimmune encephalitis regarding results of CSF analysis (larger percentage without autoimmune encephalitis had abnormal CSF analysis). There is a statistical significant difference between the studied groups with and without autoimmune encephalitis regarding prognosis. Conclusion: CSF NMDAR antibodies are highly sensitive biomarker in prediction of mortality and poor prognosis of encephalitis in children.
Keywords
CSF; Encephalitis; NMDAR; Autoimmune
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