SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES
Abd-Elhafez, A., Mohamed, H., Hassan, H., El-Karamany, G., El-Koussi, N., Youssef, A. (1997). SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES. EKB Journal Management System, 20(1), 47-61. doi: 10.21608/bfsa.1997.68738
A. A. Abd-Elhafez; H. M. Mohamed; H. Y. Hassan; G. S. El-Karamany; N. A. El-Koussi; A. F. Youssef. "SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES". EKB Journal Management System, 20, 1, 1997, 47-61. doi: 10.21608/bfsa.1997.68738
Abd-Elhafez, A., Mohamed, H., Hassan, H., El-Karamany, G., El-Koussi, N., Youssef, A. (1997). 'SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES', EKB Journal Management System, 20(1), pp. 47-61. doi: 10.21608/bfsa.1997.68738
Abd-Elhafez, A., Mohamed, H., Hassan, H., El-Karamany, G., El-Koussi, N., Youssef, A. SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES. EKB Journal Management System, 1997; 20(1): 47-61. doi: 10.21608/bfsa.1997.68738

SYNTHESIS AND INVESTIGATION OF CERTAIN 3(5)- SUBSTITUFED-1,2,4- TRIAZOLE-5(3)-CARBOXYLIC ACID DERIVATIVES

Bulletin of Pharmaceutical Sciences Assiut University
Article 7, Volume 20, Issue 1, June 1997, Page 47-61  XML PDF (805.62 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1997.68738
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Authors
A. A. Abd-Elhafez; H. M. Mohamed; H. Y. Hassan; G. S. El-Karamany; N. A. El-Koussi; A. F. Youssef
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiui, Egypt
Abstract
A series of 3(5)-substituted 1,2,4-triazole-5(3)-carboxylic acid amides, hydroxamic, hydrazide, iminosemicarbazide, semicarbazide and thiosemicarbazide have been synthesized. Most of the prepared compounds were tested for their growth inhibitory activity against Staph. aureus and E. coli and none of them revealed antibacterial activity at concentration up to 2.5 mg/mL. The 5(3)-iminosemicarbazides (8h, 9h, 10h, 11h), 5(3)-semicarbazides (8i, 9i, 10i, 11i) and 5(3)-thiosemicarbazides (8j, 9j, 10j) were chosen for evaluation of their potentialities to lower blood glucose level in rats. The oral glucose tolerance test was used as preliminary test for evaluation of hypoglycemic activity of these compounds. The tested compounds showed different onset and duration of action.
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