IN VITRO RELEASE OF FREEZE-DRIED MEFENAMIC ACID-POLOXAMER FROM SUPPOSITORY BASES AND EVALUATION OF ITS ANTI-INFLAMMATORY EFFECT | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 12, Volume 20, Issue 1, June 1997, Page 95-104 PDF (632.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1997.68745 | ||||
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| Author | ||||
| S. A. El-Harras | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The in vitro release of mefenamic acid (MFA) as well as its freeze-dried forms with poloxamer 409 (PF-127) in different ratios [(9:1), (1:1)] from suppository bases was investigated and confirmed with DSC and X-ray. The release rate of MFA from lipophilic base (WH15) and hydrophilic base (3PEG 1000:7 PEG 4000) in NaOH, KH2PO4 buffer at 37°C was performed. The release pattern of MFA:PF-127 freeze-dried samples from both selected bases was remarkably higher than that of pure untreated drug. However, the release of the drug as indicated by permeability rate constant was much more faster from WH15 compared to PEG using the same ratio of drug:PF-127 (8.037 vs 1.827, respectively). MFA:PF-127 (1:1) freeze-dried formulated in WH15 and PEG suppository bases were evaluated by the carrageenin induced rabbit hindpaw edema. Both formulas resulted in inhibition of edema formation l hr post medication (58.6%, and 41.4%, respectively) which was significantly greater than the rectal MFA as received in WH15 (14.7%). | ||||
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