FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS
Ali, A., Ali, A., Mohammed, F. (1997). FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS. EKB Journal Management System, 20(2), 141-146. doi: 10.21608/bfsa.1997.68751
Ahmed Shaker Ali; Adel Mohamed Ali; Fergany Abd El-Hameed Mohammed. "FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS". EKB Journal Management System, 20, 2, 1997, 141-146. doi: 10.21608/bfsa.1997.68751
Ali, A., Ali, A., Mohammed, F. (1997). 'FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS', EKB Journal Management System, 20(2), pp. 141-146. doi: 10.21608/bfsa.1997.68751
Ali, A., Ali, A., Mohammed, F. FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS. EKB Journal Management System, 1997; 20(2): 141-146. doi: 10.21608/bfsa.1997.68751

FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS

Bulletin of Pharmaceutical Sciences Assiut University
Article 4, Volume 20, Issue 2, December 1997, Page 141-146  XML PDF (379.21 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1997.68751
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Authors
Ahmed Shaker Ali1; Adel Mohamed Ali2; Fergany Abd El-Hameed Mohammed1
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Faculty of Pharmacy, Al-Isra University, Amman, Jordan
Abstract
Three matrix excipients namely: Hydroxypropylmethylcellulose (HPMC), sodium carboxymethyl cellulose (NaCMC) and egg albumin (EA) were utilized for the preparation of controlled release matrix tablets containing 200 mg of aminophylline. The prepared tablets were evaluated with respect to physical parameters and dissolution rate. All formulations showed acceptable physical parameters. The release rate was variable depending on the composition of the matrix tablet. There was no significant difference between the dissolution rates of the matrix tablets prepared with HPMC or EA. The lowest release rate was observed in case of the matrix tablets prepared using NaCMC either alone or in combination with either HPMC or EA. The dissolution data of the drug from most matrix tablets formulation were fitted to Higuchi diffusion model.
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