SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY
El-Koussi, N., Hassan, H., Farag, H. (1997). SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY. EKB Journal Management System, 20(2), 155-161. doi: 10.21608/bfsa.1997.68755
Nawal A. El-Koussi; Hoda Y. Hassan; Hassan H. Farag. "SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY". EKB Journal Management System, 20, 2, 1997, 155-161. doi: 10.21608/bfsa.1997.68755
El-Koussi, N., Hassan, H., Farag, H. (1997). 'SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY', EKB Journal Management System, 20(2), pp. 155-161. doi: 10.21608/bfsa.1997.68755
El-Koussi, N., Hassan, H., Farag, H. SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY. EKB Journal Management System, 1997; 20(2): 155-161. doi: 10.21608/bfsa.1997.68755

SYNTHESIS AND INVESTIGATION OF MAO INHIBITORS: HYDRAZONES OF POTENTIAL BRAIN-SPECIFIC DELIVERY

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 20, Issue 2, December 1997, Page 155-161  XML PDF (375.12 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1997.68755
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Authors
Nawal A. El-Koussi; Hoda Y. Hassan; Hassan H. Farag
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
A series of 1-methyl-3-[N-(substituted benzalimino)carbamoyl] pyridinium iodide and their corresponding dihydropyridines were prepared by conventional methods. The prepared compounds were tested in vitro for their MAO inhibitory activity on liver mitochondria by kynuramine fluorimetric assay. The results showed that MAOI activity of quaternaries is more than the corresponding dihydro compounds. 
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