Leptin exerts a bone protective effect in ovariectomized rats by inhibiting osteoclastogenesis | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 11, Volume 40, Issue 1, January 2020, Page 166-179 PDF (464.95 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2019.14749.1033 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mona Abdel-Azim said1; heba Mohamed Abdel-Kareem2; hend abouzeid abdallah  3
| ||||
| 1Physiology department, Benha Faculty of Medicine, Benha University, benha ,Egypt. | ||||
| 2Medical biochemistry department, benha Faculty of Medicine, Benha University, Egypt | ||||
| 3physiology department,Benha faculty i=of medicine,Benha university, Benha ,Egypt | ||||
| Abstract | ||||
| Osteoporosis is one of the most prevalent bone diseases especially among postmenopausal women. The study was conducted on 36 female rats divided into three equal groups; i) Sham operated; ii) Ovariectomized (OVX) ; iii) Leptin treated ovariectomized. Serum receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG), urinarydeoxypyridoline/creatinine (DPY)/Cr) were measured. The mRNA expression of RANKL and OPG were examined by real time polymerase chain reaction (PCR). Leptin decreased bone turnover markers and serum RANKL while it resulted in significant increase in serum Ca and OPG. Moreover, it had a significant anti-osteoporotic effect compared to OVX rats as it markedly down-regulated expression of RANKL and up-regulated expression of OPG in proximal femur, and thus lowered the RANKL/OPG ratio. These findings suggests that the anti-osteoporotic effect of leptin was by inhibiting osteoclastogenesis via modulating the RANKL/OPG ratio and that leptin can be used as alternative therapeutic agents of osteoporosis . | ||||
| Keywords | ||||
| leptin; Osteoporosis; bone markers; RANKL; OPG | ||||
|
Statistics Article View: 287 PDF Download: 317 |
||||
