Eco-Friendly Route for Encapsulation of 5-Fluorouracil Into Polycaprolactone Nanoparticles | ||||
Egyptian Journal of Chemistry | ||||
Article 22, Volume 63, Issue 1, January 2020, Page 255-267 PDF (1.67 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2019.19380.2182 | ||||
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Authors | ||||
Moshera Samy 1; Heba M. Abdallah2; Magdy M.H. Ayoub3; M.E. Vylegzhanina4; A.Ya. Volkov4; T.E. Sukhanova5 | ||||
1polymers and pigments, national research center,Giza,Egypt | ||||
2polymers and pigments, national research center, Giza, Egypt | ||||
3Polymers and Pigments,National research center,Giza,Egypt | ||||
4Institute of Macromolecular Compounds, Russian Academy of Sciences, Russia | ||||
5Institute of Macromolecular Compounds and S.V. Lebedev Institute of Synthetic Rubber,Russia | ||||
Abstract | ||||
The main objective of this study was to allocate and evaluate the most optimum conditions to prepare the 5-Fluorouracil (5-FU) entrapped polycaprolactone (PCL) nanoparticles (5-FU–PCNs) by eco-friendly route. The inner aqueous phase (W1) was added to solution containing PCL with homogenization to form primary emulsion (W1/O) which was emulsified with the outer aqueous phase (W2) containing polyvinyl alcohol (PVA) as stabilizer to attain the double emulsion (W1/O/W2). The different parameters were investigated to reach the most successful formulation for 5-FU–PCNs, such as polymer concentration, effect of stabilizer concentration ratio (0.5%, 1% and 3%) on drug encapsulation efficiency, etc. The encapsulation efficiency of PCNs was in the range of 14-65.6%. The prepared nanoparticles showed the spherical shape having an average size of 183-944nm.The prepared systems were elucidated by fourier transform infrared spectroscopy (FTIR), UV-spectroscopy, photon correlation spectroscopy (PCS), X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA),scanning electron (SEM) and atomic-force microscopy (AFM). The optimized ratios of the different parameters of double emulsion process were founded. SEM and AFM confirmed the complicated morphology and the formation of the spherical micro- and nanocapsules. | ||||
Keywords | ||||
Polycaprolactone, Nanoparticles, 5-Fluorouracil, Encapsulation Efficiency, Structure; Morphology, Thermal Characterization | ||||
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