Novel Heterocycles via 2-Cyano-N-arylacetamide Synthesis with Docking Studies of Novel Heterocycles as Antimicrobial Agents Utilizing 2-Cyano-N-arylacetamide | ||||
| Egyptian Journal of Chemistry | ||||
| Article 275, Volume 63, Issue 3, March 2020, Page 1075-1085 PDF (9.01 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.21812.2294 | ||||
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| Authors | ||||
Hayam A. Abdelsalaam 1; Ewies Ewies  2
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| 1Department of Green Chemistry, National Research Centre (NRC), 33 EL-Bohouth Street (former EL-Tahrir Street), Dokki Giza Egypt | ||||
| 2Organometallic and Organometalloid Chemistry, Chemical Industries Division, National Research Centre | ||||
| Abstract | ||||
| 2-CYANO-N-arylacetamide reagent is used in a straight forward synthesis of various interesting nitrogenous heterocycles such as iminocoumarine, thiazole, dihydropyridine and imidazole or benzoimidazole. Molecular docking studies are described to show the most active compounds as antimicrobial agents. Also, Biological testing of these compounds for their antimicrobial activities against some strains of Gram bacteria and strains of fungi has been carried out. | ||||
| Keywords | ||||
| Antimicrobial activities; 2-Cyano-N-arylacetamide; Iminocoumarine; Thiazole and Dihydropyridine | ||||
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