Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast
Gaffer, H., Elapasery, M., Abbas, D., Allam, E. (2020). Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast. EKB Journal Management System, 63(3), 1087-1099. doi: 10.21608/ejchem.2020.22449.2335
Hatem Gaffer; Morsy Elapasery; Dina Abbas; Emad Allam. "Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast". EKB Journal Management System, 63, 3, 2020, 1087-1099. doi: 10.21608/ejchem.2020.22449.2335
Gaffer, H., Elapasery, M., Abbas, D., Allam, E. (2020). 'Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast', EKB Journal Management System, 63(3), pp. 1087-1099. doi: 10.21608/ejchem.2020.22449.2335
Gaffer, H., Elapasery, M., Abbas, D., Allam, E. Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast. EKB Journal Management System, 2020; 63(3): 1087-1099. doi: 10.21608/ejchem.2020.22449.2335

Synthesis of Some New Aryl-azo Derivatives Clubbed with Pyridone and Evaluating their Biological Broadcast

Egyptian Journal of Chemistry
Article 276, Volume 63, Issue 3, March 2020, Page 1087-1099  XML PDF (1.19 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.22449.2335
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Authors
Hatem Gaffer email 1; Morsy Elapaseryorcid 2; Dina Abbas1; Emad Allam3
1Dyeing, Printing and Auxiliaries Department, Textile Industries Research Division, National Research Centre, 33 El-Buhouth Street, Dokki, Cairo 12622, Egypt.
2Dyeing, Printing and Auxiliaries Department, Textile Research Division, National Research Centre, Cairo 12622, Egypt
3Textile Printing, Dyeing and Finishing Department, Faculty of Applied Arts Helwan University, Cairo 12622, Egypt.
Abstract
SYNTHESIS of some new Aryl-azopyridone analogues was synthesized through coupling of diverse Diazonium salts with 1-ethyl-4-methyl-2,6-dioxopiperidine-3-carbonitrile. The proper structures for all incorporated derivatives were demonstrated to be confirmed via various physical and spectral analyses performed. The synthesized analogues were probed as cytotoxic agents toward four dissimilar cell lines, in which the results displayed persuasive activities relative to the results of antibiotic standards. In addition, the antioxidant activity of the synthesized analogues was evaluated using ABTS•+ method.
Keywords
Anticancer activities; antioxidant; Cytotoxicity; Diazonium salts; Pyridones
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