Alterations of the Cerebellar Cortical Structure after Aluminum Chloride Perinatal Exposure in Albino Rats. Does Omega-3 Minimize the Noxious Effect of Aluminum?
Albakoush, K., Maher, I., Hulail, M., Abd El- Fatah, S. (2022). Alterations of the Cerebellar Cortical Structure after Aluminum Chloride Perinatal Exposure in Albino Rats. Does Omega-3 Minimize the Noxious Effect of Aluminum?. EKB Journal Management System, 28(5), 1057-1067. doi: 10.21608/zumj.2020.21229.1658
Khalid Mohammed Albakoush; Ibrahim Amin Maher; Mohey El-sayed Hulail; Samaa Salah Abd El- Fatah. "Alterations of the Cerebellar Cortical Structure after Aluminum Chloride Perinatal Exposure in Albino Rats. Does Omega-3 Minimize the Noxious Effect of Aluminum?". EKB Journal Management System, 28, 5, 2022, 1057-1067. doi: 10.21608/zumj.2020.21229.1658
Albakoush, K., Maher, I., Hulail, M., Abd El- Fatah, S. (2022). 'Alterations of the Cerebellar Cortical Structure after Aluminum Chloride Perinatal Exposure in Albino Rats. Does Omega-3 Minimize the Noxious Effect of Aluminum?', EKB Journal Management System, 28(5), pp. 1057-1067. doi: 10.21608/zumj.2020.21229.1658
Albakoush, K., Maher, I., Hulail, M., Abd El- Fatah, S. Alterations of the Cerebellar Cortical Structure after Aluminum Chloride Perinatal Exposure in Albino Rats. Does Omega-3 Minimize the Noxious Effect of Aluminum?. EKB Journal Management System, 2022; 28(5): 1057-1067. doi: 10.21608/zumj.2020.21229.1658

Alterations of the Cerebellar Cortical Structure after Aluminum Chloride Perinatal Exposure in Albino Rats. Does Omega-3 Minimize the Noxious Effect of Aluminum?

Zagazig University Medical Journal
Article 20, Volume 28, Issue 5, September 2022, Page 1057-1067  XML PDF (1001.85 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.21229.1658
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Authors
Khalid Mohammed Albakoush email 1; Ibrahim Amin Maher2; Mohey El-sayed Hulail3; Samaa Salah Abd El- Fatah4
1M.B.B.Ch., Department of Anatomy & Embryology, Faculty of Medicine, Almergib University , Libya
2Professor of Anatomy & Embryology, Faculty of Medicine - Zagazig University
3Professor and head of Anatomy & Embryology Department, Faculty of Medicine ;Zagazig University
4Lecturer of Anatomy & Embryology, Faculty of Medicine - Zagazig University
Abstract
Backgrounds: Aluminum (AL) is a well-known neurotoxin that impedes more than 200 biologically essential tasks, with effects such as reduced cognitive functions and severe behavioral irregularities. Omega-3 fatty acid is an essential nutrient that may antagonize AL-neurotoxicity. Aim of work: the current study aimed to illustrate the possible protective role of omega-3 on perinatal AL exposure on cerebellar cortical structure in albino pups. Materials and methods: After mating, 28 pregnant female rats were divided equally into four groups. All treated groups received drugs from day 14 (D14) of gestation until D21 after birth. The pups of each group were divided into subgroups according to the day of sacrifice, either postnatal D14 or D21. Cerebellum specimens were processed for light microscopy, immunohistochemistry, and morphometric, and biochemical studies. Results: There was a significant decrease in weight gain and superoxide dismutase (SOD) levels and significant increase in the malondialdehyde (MDA) levels compared to the respective groups. The AL-treated groups revealed alteration in the thickness of different cerebellar cortical layers, decrease Purkinje cell count and increase optical density of caspase-3 immunostaining at postnatal D14 and D21. Conclusion: The cerebellar cortical structure revealed marked alterations in albino pups after exposure of their mother to AL during gestation and lactation periods. Omega-3 played a protective role against AL- toxicity.
Keywords
Aluminum; Omega3; developing cerebellum; albino rat offspring
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