DESIGN, SYNTHESIS AND EVALUATION OF SOME NOVEL 3-ALLYL-6-IODO-2-SUBSTITUTED THIOQUINAZOLINONE DERIVATIVES FOR ANTICONVULSANT ACTIVITY | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 11, Volume 50, Issue 2 - Serial Number 50, September 2014, Page 154-172 PDF (962.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2016.6950 | ||||
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| Author | ||||
| Menshawy Mohamed | ||||
| Department of Pharmaceutical Chemistry, College of Pharmacy, Salman bin Abdulaziz University, Alkharj, Saudi Arabia. /Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| The urgent demand for the development of new antiepileptic drug with a better efficacy inspired us to design and synthesize a new derivatives of the fused heterocyclic analogs 3-allyl-6-iodo-2-(substituted thio)quinazolin-4(3H)-one that prepared and evaluated for their anticonvulsant activity. Compounds 10, 11, 12, 13, 14 and 22 were found to be the most active anticonvulsant of this series. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues. | ||||
| Keywords | ||||
| Synthesis; 3-allyl-6-iodo-2-(substituted thio)quinazolin-4(3H)-one; anticonvulsant screening; pentylenetetrazole | ||||
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