OCULAR BIOAVAILABILITY OF PREDNISOLONE FROM MULTIPLE EMULSION DELIVERY SYSTEMS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 2, Volume 18, Issue 1, June 1995, Page 15-21 PDF (420.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1995.69665 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| M. A. Kassem; S. M. Safwat; M. A. Attia; M. M. El-Mahdy | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Studies were conducted to evaluate the performance of prednisolone in multiple emulsions as drug delivery systems on the inflamed rabbit's eye. Multiple emulsions w/o/w and o/w/o were prepared by re-emulsification technique. Evaluation of the emulsions was done immediately after the preparation by microscopical examination. Topical instillation of simple emulsion treatments were also investigated for the purpose of comparison. Follow up of the outcome of control and test treatments was made daily by instillation of fluorescein solution and counting the number of induced ulcers. The comparison of the healing rate in control and test treatments groups showed marked differences between the groups. These differences are not only pronounced with regard to the rate of healing but also to its extent. Statistical analysis of differences between the control group and the different test groups with regard to the number of residual ulcers throughout the observation period of four weeks was made according to the student t-test. | ||||
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