SEMICARBAZONES AS ANTICONVULSANTS | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 16, Volume 49, Issue 1 - Serial Number 49, March 2014, Page 220-241 PDF (461.3 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2014.6969 | ||||
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| Author | ||||
| Mohamed Aboul-Enein | ||||
| Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza,12622, Egypt | ||||
| Abstract | ||||
| Approximately 25% of epileptics’ convulsions are inefficiently controlled by currently available remedies; therefore the preparation of new antiepileptic drugs is of great interest. Aryl semicarbazones can be considered a new class of compounds presenting anticonvulsant activity. In addition, they can be orally administered. Semicarbazones derived from aromatic and unsaturated carbonyl compounds as well as from other precursors are reviewed together with their anticonvulsant profile. | ||||
| Keywords | ||||
| Semicarbazone; Anticonvulsant; pentylenetetrazole (PTZ); maximal electroshock (MES) | ||||
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