HAEMATOXYLIN-PERMANGANATE REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF SOME THIOL DRUGS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 10, Volume 18, Issue 2, December 1995, Page 135-141 PDF (434.1 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1995.69706 | ||||
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| Author | ||||
| Ibrahim H. Refaat | ||||
| Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A new rapid and sensitive spectrophotometric method was developed for the determination of six thiol pharmaceutical compounds. The method is based on the spontaneous oxidation of the thiol group with a constant small concentration of potassium permanganate followed by the rapid reaction of the excess permanganate with haematoxylin reagent in neutral aqueous medium. Haematoxylin is oxidized to the coloured chromogen, haematein which was measured at 558 nm. A linear relationship was obtained between drug concentration and the decrease in absorbance readings. The method was applied for the determination of the investigated compounds either in authentic powders or in some .dosage forms. Good agreement was obtained with the reported methods. In addition, the suggested method was tried as stability indicating assay for the investigated thiol drugs. | ||||
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