SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY
Ashour, F., El-Hawash, S., Mahran, M., Yousry, A., Harnouda, A. (1994). SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY. EKB Journal Management System, 17(1), 17-25. doi: 10.21608/bfsa.1994.69784
F. A. Ashour; S. A. M. El-Hawash; M. A. Mahran; A. H. Yousry; A. F. Harnouda. "SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY". EKB Journal Management System, 17, 1, 1994, 17-25. doi: 10.21608/bfsa.1994.69784
Ashour, F., El-Hawash, S., Mahran, M., Yousry, A., Harnouda, A. (1994). 'SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY', EKB Journal Management System, 17(1), pp. 17-25. doi: 10.21608/bfsa.1994.69784
Ashour, F., El-Hawash, S., Mahran, M., Yousry, A., Harnouda, A. SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY. EKB Journal Management System, 1994; 17(1): 17-25. doi: 10.21608/bfsa.1994.69784

SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW 1,3,4-OXADIAZOLES AND 2-SUBSTITUTED AMINO-L,3,4-OXADIAZOLE DERIVATIVES CONTAINING BENZIMIDAZOLE MOIETY

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 17, Issue 1, July 1994, Page 17-25  XML PDF (435.37 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1994.69784
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Authors
F. A. Ashour1; S. A. M. El-Hawash1; M. A. Mahran1; A. H. Yousry2; A. F. Harnouda2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
2Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt
Abstract
New 2-[4-(3-acetyl-2-substituted- 2,3-dihydro-1,3,4-oxadiazol-5-yl)phenoxymethyl]-1H-bezimidazoles (V) and 2-[4-(3-acetyl-2-substituted-2,3-diydro-1,3,4-oxadiazol-5yl)phenoxymetyl]-1-methyl-1H-benzimidazoles (VI) were synthesized by cyclization of 2-[4-alkylidene or arylidenehydrazinocarbonyl)phenoxymethyl]-1H-benzimidazoles (III) or 2-[4-(alkylidene or arylidenehydrazinocarbonyl)phenoxymethyl]-1-methyl-1H-benzimidazoles (IV) with acetic anhydride.
New series of 2-[4-substitutedamino-1,3,4-oxadiazol-5-yl)phenoxymethyl]-1H-benzimidazoles (IX) and 2-[4-substitutedamino-1,3 ,4-oxadiazol-5-yl)phenoxymethyl]-1-methyl-1H-benzimidazoles (X) were obtained by cyclodesulfurization of 2-[4-(substitutedthiocarbamoylhydrazinocarbonyl)phenoxymethyl]-1H-benzimidazoles (VII) or 2-[4-(substitutedthiocarbamoylhydrazi nocarbonyl)phenoxymethyl]-1-methyl-1H-benzimidazoles (VIII). The structure of the newly synthesized compounds were elucidated by elemental analysis, IR and 1H-NMR spectra. Their antimicrobial activity was studied.
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