DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES
Hassan, H., El-Shorbagi, A., El-Koussi, N., Abdel-Zaher, A. (1994). DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES. EKB Journal Management System, 17(1), 27-39. doi: 10.21608/bfsa.1994.69785
Hoda Y. Hassan; Abdel-Nasser A. El-Shorbagi; Nawal A. El-Koussi; Ahmed O. Abdel-Zaher. "DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES". EKB Journal Management System, 17, 1, 1994, 27-39. doi: 10.21608/bfsa.1994.69785
Hassan, H., El-Shorbagi, A., El-Koussi, N., Abdel-Zaher, A. (1994). 'DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES', EKB Journal Management System, 17(1), pp. 27-39. doi: 10.21608/bfsa.1994.69785
Hassan, H., El-Shorbagi, A., El-Koussi, N., Abdel-Zaher, A. DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES. EKB Journal Management System, 1994; 17(1): 27-39. doi: 10.21608/bfsa.1994.69785

DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES

Bulletin of Pharmaceutical Sciences Assiut University
Article 3, Volume 17, Issue 1, July 1994, Page 27-39  XML PDF (634.31 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1994.69785
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Authors
Hoda Y. Hassan1; Abdel-Nasser A. El-Shorbagi2; Nawal A. El-Koussi1; Ahmed O. Abdel-Zaher3
1Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt
3Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
Abstract
The synthesized 1H-1,2,4-triazoles (7a-c, 8a-c and 9a-c), a novel class of heterocyclic compounds of potential anti-inflammatory and analgesic activities, are of interest, since they present some differences compared to the classical non-steroidal anti-inflammatory agents. The anti-inflammatory activity of all derivatives was studied in albino rats using trypan-blue and kaolin-induced edema methods. The compounds were also tested in albino mice for their analgesic activity using the hot plate and p-benzoquinone-induced writhing methods. A correlation between the structures, pharmacological actions and the calculated partition coefficients of the products was studied.
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