DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 3, Volume 17, Issue 1, July 1994, Page 27-39 PDF (634.31 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1994.69785 | ||||
View on SCiNiTO | ||||
Authors | ||||
Hoda Y. Hassan1; Abdel-Nasser A. El-Shorbagi2; Nawal A. El-Koussi1; Ahmed O. Abdel-Zaher3 | ||||
1Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt | ||||
2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt | ||||
3Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt | ||||
Abstract | ||||
The synthesized 1H-1,2,4-triazoles (7a-c, 8a-c and 9a-c), a novel class of heterocyclic compounds of potential anti-inflammatory and analgesic activities, are of interest, since they present some differences compared to the classical non-steroidal anti-inflammatory agents. The anti-inflammatory activity of all derivatives was studied in albino rats using trypan-blue and kaolin-induced edema methods. The compounds were also tested in albino mice for their analgesic activity using the hot plate and p-benzoquinone-induced writhing methods. A correlation between the structures, pharmacological actions and the calculated partition coefficients of the products was studied. | ||||
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