PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 17, Issue 1, July 1994, Page 73-79 PDF (486.3 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1994.69790 | ||||
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| Authors | ||||
| S. A. El-Harras1; S. Shawky1; E. Hafez1; S. Shaker2 | ||||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Lyophilization technique has been adopted to enhance the aqueous solubility of diazepam. Two hydrophilic polymers namely; polyvinyl pyrrolidone 44000 (PVP) and pluronic F-127 (PF-127) in different ratios were used as the adjuvents in preparing the freeze-dried samples. Of the tested ratios, diazepam: PVP (1:10) and diazepam: PF-127 (1:60) were found to gave the highest solubility of the drug. The dissolution studies revealed that lyophilized diazepam samples required from 1-3 minutes to dissolve compared to 20 minutes in case of untreated drug. Histological evaluations were performed after S.C. and I.M. injection into mice. A slight histological changes were induced. Consequently, the prepared lyophilized-diazepam product can be reconstituted with ease using phosphate buffer (pH 7.2) for parenteral administration, as well as it can met the requirement of zydis. | ||||
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