FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E
Habib, F., Nakai, Y., El-Sayed, A., Ali, A. (1994). FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E. EKB Journal Management System, 17(2), 119-125. doi: 10.21608/bfsa.1994.69798
F. S. Habib; Yoshinbu Nakai; A. M. El-Sayed; A. S. Ali. "FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E". EKB Journal Management System, 17, 2, 1994, 119-125. doi: 10.21608/bfsa.1994.69798
Habib, F., Nakai, Y., El-Sayed, A., Ali, A. (1994). 'FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E', EKB Journal Management System, 17(2), pp. 119-125. doi: 10.21608/bfsa.1994.69798
Habib, F., Nakai, Y., El-Sayed, A., Ali, A. FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E. EKB Journal Management System, 1994; 17(2): 119-125. doi: 10.21608/bfsa.1994.69798

FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E

Bulletin of Pharmaceutical Sciences Assiut University
Article 4, Volume 17, Issue 2, December 1994, Page 119-125  XML PDF (421.05 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1994.69798
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Authors
F. S. Habib1; Yoshinbu Nakai2; A. M. El-Sayed1; A. S. Ali1
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoicho, Chiba 263, Japan
Abstract
Porous calcium silicate (florite R) and controlled pore glass (CPG 75 & CPG 500) were investigated as carriers to formulate vitamin E in a free flowing powder form. The prepared dispersions were subjected to thermogravemetric analysis (TG), scanning electron microscopic examination, testing of flow ability, uniformity of content and in-vitro release of vitamin E.
TG of vitamin E - porous silicas. dispersions indicated that vitamin E existed in both lightly and strongly bound state. The latter was directly related to the specific surface area of the carrier. Florite R was found to have a greater ability to hold vitamin E than controlled pore glass. the dispersions prepared using florite R and containing up to 40% w/w vitamin E showed good flowability, uniformity of content and almost 100% release of the loaded drug.
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