EFFECT OF FORMULATION VARIABLES OF MULTIPLE EMULSION ON THE STABILITY AND ANTITREMOR ACTIVITY OF CHLORPHENOXAMINE HYDROCHLORIDE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 17, Issue 2, December 1994, Page 165-176 PDF (762.04 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1994.69802 | ||||
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| Authors | ||||
| S. M. Safwat1; I. M. Samy2; M. Abdel-Rahman3 | ||||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 3Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| W/O/W multiple emulsion formulations of chlorphenoxamine hydrochloride were prepared. The results of dissolution indicate that the release of the drug from w/o/w multiple emulsion was significantly sustained.. The incorporation of the additives into the external aqueous phase of w/o/w multiple emulsions based on liquid paraffin increased the release of the drug in the following order: sodium chloride >' Polyvinyl alcohol > hydroxypropyl methylcellulose > polyvinylpyrrolidone. Stability studies of differentemulsion samples were conducted at various temperatures and, evaluated by using the conductivity method. The obtained data indicated that the emulsions were stable during the storage for 3 months at 25°C. The formula (Fm) of the multiple emulsion which contained castor oil with Span 60 possessed a more efficient prolonged antitremor effect and lowered of spontaneous locomotor activity (SLMA) in mice than that of the drug solution. The statistical analysis also revealed that this formula produced a greater sedative effect compared with that of the drug solution. | ||||
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