ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC
Abdel Rahman, A., Aboutaleb, A., Stamm, A., Abdel Rahman, S., Samy, E. (1993). ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC. EKB Journal Management System, 16(1), 1-11. doi: 10.21608/bfsa.1993.70021
Aly A. Abdel Rahman; A. E. Aboutaleb; A. Stamm; S. I. Abdel Rahman; E. M. Samy. "ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC". EKB Journal Management System, 16, 1, 1993, 1-11. doi: 10.21608/bfsa.1993.70021
Abdel Rahman, A., Aboutaleb, A., Stamm, A., Abdel Rahman, S., Samy, E. (1993). 'ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC', EKB Journal Management System, 16(1), pp. 1-11. doi: 10.21608/bfsa.1993.70021
Abdel Rahman, A., Aboutaleb, A., Stamm, A., Abdel Rahman, S., Samy, E. ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC. EKB Journal Management System, 1993; 16(1): 1-11. doi: 10.21608/bfsa.1993.70021

ACCELERATED STABILITY TESTING OF IBUPROFEN-EUDRAGIT RSPM SUSTAINED RELEASE TABLETS USING 1H-NMR, HPLC AND TLC

Bulletin of Pharmaceutical Sciences Assiut University
Article 1, Volume 16, Issue 1, June 1993, Page 1-11  XML PDF (546.71 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1993.70021
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Authors
Aly A. Abdel Rahman1; A. E. Aboutaleb1; A. Stamm2; S. I. Abdel Rahman1; E. M. Samy1
1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Faculty of Pharmacy, Louis Pasteur University, France
Abstract
Ibuprofen-Eudragit RSPM sustained release tablets, already have been formulated, were subjected to accelerated stability testing for 6 months at 25, 37 and 45°C.The tablets were stored in firmly closed glass bottles in order to eliminate the effect of humidity, a condition simulating the actual shelf storage.
The drug content of the stored tablets was evaluated using 1H-NMR, HPLC and TLC techniques in order to investigate the effect of temperature on ibuprofen stability.
A small reduction (2-4 % w/w) in the drug content was detected in the tablets stored at 37 and 45°C for 6 months using 1H-NMR and HPLC techniques. The decomposition of ibuprofen in the preformulated tablets was found to be first order reaction kinetics.
It was concluded that the expiry date of ibuprofen in the formulated sustained release tablets is up to 3 years. Thus this formulation could be considered as a convenient pharmaceutical formulation of ibuprofen.
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