EVALUATION OF IBUPROFEN-CELLULOSIC POLYMERS SUSTAINED RELEASE TABLETS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 3, Volume 16, Issue 1, June 1993, Page 25-35 PDF (647.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1993.70026 | ||||
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| Authors | ||||
| Aly A. Abdel Rahman1; A. E. Aboutaleb1; A. Stamm2; S. I. Abdel Rahman1; E. M. Samy1 | ||||
| 1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Faculty of Pharmacy, Louis Pasteur University, France | ||||
| Abstract | ||||
| Ibuprofen sustained release tabletse were formulated using wet granulation technique and cellulosic polymers as granulating agents including ethyl cellulose 20, hydroxypropyl methyl cellulose (pharmacoat 606) and hydroxypropyl methyl cellulose phthalate (HP 55 F). The effect of tablet excipients including Avicel PH 102, Lactose, Emcompress and Emedex on the release rate of ibuprofen from the prepared tablets was also investigated using shift dissolution method. It was found that among the formulated ibuprofen sustained release tablets, those tablets granulated with 3% w/v ethyl cellulose 20 and containing 23% Emcompress as an excipient were proved to be superior for ibuprofen sustained release. Higher Avicel PH 102 concentration (39 and 40% w/w) was found to enhance the release. Comparing the effect of 1% w/v of the investigated cellulosic polymers on ibuprofen retardation, it was found to be in the following order: ethyl cellulose 20 > HP 55 F > pharmacoat 606. Various kinetic models including zero order, first order and Higuchi equation were applied to explain the release mechanism from the prepared tablets. It was found that the best fit with the highest correlation coefficient was achieved with the zero-order equation. | ||||
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