THE MODE OF INCLUSION COMPLEXATION OF BROMAZEPAM WITH DIMETHYL -CYCLODEXTRIN | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 5, Volume 16, Issue 1, June 1993, Page 47-55 PDF (457.74 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1993.70028 | ||||
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Authors | ||||
S. I. Saleh1; Aly A. Abdel-Rahman1; A. E. Aboutaleb1; Y. Nakai2; M. O. Ahmed1 | ||||
1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
2Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan | ||||
Abstract | ||||
Inclusion complex formation of bromazepam with heptakis- (2 ,6-di-O-methyl)-b-cyclodextrin (DM-b-CD) in aqueous solution was confirmed by the solubility method. AL-type phase solubility diagram was obtained with 50 folds increase in the solubility of bromazepam. Crystalline inclusion complexes of bromazepam with DM-b-CD in 1 : 1 and 1 : 2 molar ratios were obtained by the co-precipitation method as indicated by the X-ray diffraction analysis. Infrared (IR) spectra of the inclusion complex ,of bromazepam and DM-b-CD was different depending on the molar ratio, whether it is 1: 1 or 1 : 2. In the same time, the differential scanning calorimetry (DSC) analysis showed different thermal behaviour depending on the molar ratio of the inclusion complex. These results revealed that the mode of molecular interaction of 1 : 1 inclusion complex of bromazepam with DM-b-CD was different from that of 1 : 2. | ||||
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