SUSTAINED RELEASE FORMULATIONS OF PHENAZOPYRIDINE HYDROCHLORIDE WITH CELLULOSE ACETATE PHTHALATE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 16, Issue 1, June 1993, Page 63-72 PDF (426.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1993.70030 | ||||
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| Authors | ||||
| A. M. Aly; S. M. Ahmed; S. I. Abdel-Rahman; S. I. Saleh; A. E. Aboutaleb | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Cellulose acetate phthalate (CAP) was utilized for the preparation of sustained release formulations of phenazopyridine hydrochloride (PHCl) by three different techniques: (a) solid dispersion (coprecipitation), (b) microencapsulation. by phase separation coacervation using non-solvent addition technique and (c) pan coating. The three techniques studied resulted in different extents of sustaining the release of PHCl, in vitro, compared to the untreated drug. Pan coating proved to be the easiest and most convenient: technique for the preparation of sustained release PHCl microcapsules. With regard to the release kinetics of PHCl from each of the formulations prepared, the first order model was found to be the most suitable mechanism describing the release of the drug. | ||||
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