FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 11, Volume 16, Issue 1, June 1993, Page 106-111 PDF (681.11 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1993.70034 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A. A. Habeeb; M. M. Mabrouk | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt | ||||
| Abstract | ||||
| A highly sensitive fluorometric method for determination of acyclovir is described. The method depends on the interaction between acyclovir .and 7-hydroxy-4-methylcoumarin where a fluorophore of high fluorogenic activity is formed which has wavelengths of maximum excitation and emission of 342 and 452,respectively. The method is used for determination of acyclovir in human plasma in the range of 5-10 ngm-1 in a rectilinear relationship. The mean percentage recovery was 99.954 S.D. ± 1.450 in case of bulk drug while it was 99.893 S.D.+ 0.711 in case of 6 concentrations of human plasma. The method is recommended for drug monitoring of acyclovir. | ||||
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