SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE
El-Kommos, M., Mohamed, H., Abdelmageed, O., Mohamed, N. (1993). SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE. EKB Journal Management System, 16(2), 131-139. doi: 10.21608/bfsa.1993.70042
M. E. El-Kommos; H. A. Mohamed; O. H. Abdelmageed; N. A. Mohamed. "SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE". EKB Journal Management System, 16, 2, 1993, 131-139. doi: 10.21608/bfsa.1993.70042
El-Kommos, M., Mohamed, H., Abdelmageed, O., Mohamed, N. (1993). 'SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE', EKB Journal Management System, 16(2), pp. 131-139. doi: 10.21608/bfsa.1993.70042
El-Kommos, M., Mohamed, H., Abdelmageed, O., Mohamed, N. SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE. EKB Journal Management System, 1993; 16(2): 131-139. doi: 10.21608/bfsa.1993.70042

SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE

Bulletin of Pharmaceutical Sciences Assiut University
Article 3, Volume 16, Issue 2, December 1993, Page 131-139  XML PDF (443.73 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1993.70042
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Authors
M. E. El-Kommos; H. A. Mohamed; O. H. Abdelmageed; N. A. Mohamed
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
The reaction of thiols with 2,6-dichloroquinone-4-chlorimide (DQC) at pH 7-8 was applied to the quantitative determination of 9 thiol compounds related to different classes (aliphatic, aromatic and heterocyclic). The aliphatic thiols yielded a yellow color (lmax 435 nm) aromatic thiols yielded an orange color (lmax 498-503 nm), sulphathiourea, 2-thiobarbituric acid and thiacetazone yielded violet colors (lmax 540-550 nm). Job's plots indicate a 1:1 ratio of thiol to reagent. Beer-lambert's law is adhered to over the following ranges 2-4 mg ml-1 (for 2-thiobarbituric acid), 3-6 mg ml-1 (for thiosalicylic acid), 4-18mg ml-1 (for thiomersal), 2-14 mg ml-1 (for thiacetazone) 10-70 mg ml-1 (for captopril), 5-25mg ml-1 (for dimercaprol), 10-40 mg ml-1 (for thioglycerol) and 5-30 mg ml-1 (for tiopronin). Common tablet excipient as well as additives in parenteral solutions were found not to interfere. The results of analysis of pure drugs and their dosage forms by the proposed method are ingood agreement with those obtained by official and reported methods.
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