SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES
El-Gendy, M., Farag, H., Abmed, A., Stedman, J., Alkaramany, G. (1992). SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES. EKB Journal Management System, 15(1), 9-21. doi: 10.21608/bfsa.1992.70208
M. A. El-Gendy; H. H. Farag; A. N. Abmed; J. R. Stedman; G. S. Alkaramany. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES". EKB Journal Management System, 15, 1, 1992, 9-21. doi: 10.21608/bfsa.1992.70208
El-Gendy, M., Farag, H., Abmed, A., Stedman, J., Alkaramany, G. (1992). 'SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES', EKB Journal Management System, 15(1), pp. 9-21. doi: 10.21608/bfsa.1992.70208
El-Gendy, M., Farag, H., Abmed, A., Stedman, J., Alkaramany, G. SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES. EKB Journal Management System, 1992; 15(1): 9-21. doi: 10.21608/bfsa.1992.70208

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 15, Issue 1, 1992, Page 9-21  XML PDF (501.2 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1992.70208
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Authors
M. A. El-Gendy1; H. H. Farag1; A. N. Abmed1; J. R. Stedman2; G. S. Alkaramany1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2School of Pharmacy, Temple University, Philadelphia, USA
Abstract
The synthesis of certain imidazo[4,5-b]pyridine derivatives namely;3-(p-(un)substitutedphenacyl) imidazo[4,5-b]pyridin-2-ones, their ketoximes and 1,3-bis(p-(un)substitutedphenacyl)imidazo[4,5-b]pyridin-2-ones, were under-taken. In addition the synthesis of a series of 2-methylaminoimidazo[4,5-b]pyridines and their corresponding ketoximes are discussed. Some of the synthesized imidazo[4,5-b]-pyridin-2-ones derivatives showed reasonable analgesic activity in comparison to Aspirin and Indomethacin. Compounds of 2-methylaminoimidazo [4,5-b] pyridines and their corresponding ketoximes have been tested for their anthelmintic activity against Ascaris Vitulorum of cattle in comparison to Mebendazole.
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