PREPARATION AND EVALUATION OF CLONAZEPAM SOLID DISPERSIONS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 15, Issue 1, 1992, Page 49-56 PDF (304.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1992.70215 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A. A. Abdel Rahman; S. I. Saleh; S. M. Ahmed; G. M. Mahrous | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Preparation of clonazepam solid dispersions was carried out using certain hydrophilic carriers including polyethylene glycol 2000, (PEG 2000) polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), polyvinyl pyrrolidone 44000 (PVP 44000), Myrj 52, Myrj 53 and Myrj 59. The solvent method was adopted for the preparation of the investigated solid dispersions which were subjected to ultraviolet, differential scanning calorimetry (DSC) and dissolution evaluation. It was found that dissolution enhancement was obtained from the prepared co-precipitates compared to the drug alone. The type of the carriers used, their chemical natures and their molecular weights have pronounced effects on the dissolution rate of the drug. | ||||
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