EVALUATION OF TABLETED CINNARIZINE-MICROCRYSTALLINE CELLULOSE GROUND MIXTURE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 15, Issue 1, 1992, Page 57-62 PDF (279.32 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1992.70216 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S. M. Ahmed; S. I. Saleh; A. E. Aboutaleb | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Fast release cinnarizine (CN) tablets were prepared by the direct compression of CN-microcrytalline cellulose (1:3) ground mixture. Directly compressed tablets containing either untreated CN or ground CN were also prepared for comparison. Avicel PH 101 was used as the direct compression excipient in each case. The produced tablets were evaluated with regard to their dissolution characteristics, their drug content uniformity and their physical properties including uniformity of weight, hardness, friability and disintegration time. Tablets compressed containing CN-microcrystalline cellulose ground mixture showed good physical properties, better drug content uniformity and superior dissolution characteristics compared to the tablets containing untreated or ground alone CN. | ||||
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