SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 15, Issue 1, 1992, Page 83-88 PDF (226.53 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1992.70218 | ||||
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| Author | ||||
| Abd-El Hamid N. Ahmed | ||||
| Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The reaction of 8-hydroxyquinoline I with epichlorohydrin in the presence of potassium carbonate yielded a mixture of the epoxide II and the chlorohydrin III. The reaction of certain amines with a mixture of II and III afforded 8-[2-hydroxy-3-(substitutedamino) propoxy] quinoline IVa-h. The structure of the synthesized compounds was established by microanalyses and 1H-NMR spectra. The hydrolytic rate constants in aqueous solution at pH 7 and pH 12 were determined using HPLC technique. | ||||
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