FACTORS AFFECTING CHLORDIAZEPOXIDE SOLUBILIZATION BY NON-IONIC SURFACTANTS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 5, Volume 14, Issue 1, 1991, Page 35-45 PDF (587.73 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1991.70373 | ||||
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| Authors | ||||
| A. A. Abdel Rahman; A. E. Aboutaleb; E. M. Samy | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Ceratain factors affecting chlordiazepoxide solubilization in series of non-ionic surfactant solutions were investigated viz., surfactant structure, the pH, the temperature and the incorporation of certain hydroxylated organic additives. Polysorbate 80 was more efficient for the drug solubilization than polysorbate 20 and Brij 35 was more efficient than Brij 58. On the other hand Eumulgin C1000 was found to be more efficient than Eumulgin C1500 and Myrj 52 was more than Myrj 53 than Myrj 59. Increasing the pH of Eumulgin and Brij solutions caused a gradual decrease in the quantity of the drug solubilized. Nukerjee treatment was adopted to quantify the role of both the core and capsular regions of Myrj micelles in solubilizing the drug. The drug was solubilized in Eumulgin and Brij series containing 5 or 10% w/v propylene glycol, glycerol, PEG 400 and PEG 4000. Brij 35 containing 5% w/v propylene glycol was the most efficient solubilizer for chlordiazepoxide. The distribution coefficient, Km, of the drug between the micellar and aqueous phases was calculated. | ||||
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