DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL II- CLAY SORBATE SYSTEMS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 14, Issue 1, 1991, Page 61-73 PDF (740.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1991.70375 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| H. Abdel Monem Sayed1; A. M. El-Sayed1; A. Hamed Osman2; M. Fathy1 | ||||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Chest, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Salbutamol is an effective drug in the treatment of bronchial asthma. The adsorption of salbutamol onto various clays viz., veegum HV, bentonite and magnesium trisilicate was investigated. The optimal conditions for loading the drug onto the clays were determined. The drug release from its sorbates indicates the need for a diffusion barrier to modify the drug release profile. Cellulose acetate butyrate at 1:1 core : coat ratio was used as a coating material. The coated drug sorbates offered an acceptable release profile of the drug. Coated sorbates prepared by using drug loaded onto veegum HV as the core were used to prepare a sustained release formulation of the drug. The formulation was tested in asthmatic patients and compared to the plain drug by measuring some pulmonary functions. The administration of the sustained release formulation twice daily gave the same or better improvement than that of the plain drug given three times a day. | ||||
|
Statistics Article View: 81 PDF Download: 140 |
||||
