A STUDY OF THE INCLUSION COMPLEX OF AMOBARBITAL WITH HEPTAKIS (2,6-DI-O-METHYL)--CYCLODEXTRIN | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 14, Issue 1, 1991, Page 74-81 PDF (331.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1991.70376 | ||||
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| Authors | ||||
| M. G. Abd El-Mohsen1; H. A. Mohamed2 | ||||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Analytical Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The inclusion complex of amobarbital, a hypnotic and sedative agent, with heptakis (2,6-di-o-methyl)-b-cyclodextrin (DMCD) in aqueous solution and in the solid phase was studied by the solubility method, UV spectroscopy, infrared spectroscopy (IR) ,differential scanning calorimetry (DSC) and X-ray diffractometry. The inclusion complex was confirmed to be 1: 1. The solid complex of amobarbital with DMCD in 1:1 molar ratio was prepared by coprecipitation method. The solubility and dissolution characteristics of the solid complex in water at 37±1 °C were examined. The complex formation constant, Kc, was calculated from the slope and intercept of the AL solubility diagram (950 M-1). The dissolution rate of amobarbital was significantly enhanced by the complexation with DMCD specially in the initial period of dissolution. The hypnotic effect of amobarbital and its complex given orally to mice was evaluated. The inclusion complex, showed a decrease in the onset of action and an increase in the duration of hypnotic effect. | ||||
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