FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT
Ibrahim, S., Hafez, E., El-Shanawany, S., El-Gibaly, I., Ali, S. (1991). FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT. EKB Journal Management System, 14(1), 82-94. doi: 10.21608/bfsa.1991.70377
S. A. Ibrahim; E. Hafez; S. M. El-Shanawany; I. S. El-Gibaly; S. A. Ali. "FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT". EKB Journal Management System, 14, 1, 1991, 82-94. doi: 10.21608/bfsa.1991.70377
Ibrahim, S., Hafez, E., El-Shanawany, S., El-Gibaly, I., Ali, S. (1991). 'FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT', EKB Journal Management System, 14(1), pp. 82-94. doi: 10.21608/bfsa.1991.70377
Ibrahim, S., Hafez, E., El-Shanawany, S., El-Gibaly, I., Ali, S. FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT. EKB Journal Management System, 1991; 14(1): 82-94. doi: 10.21608/bfsa.1991.70377

FORMULATION AND EVALUATION OF SOME TOPICAL ANTIMYCOTICS 3- EFFECT OF PROMOTORS ON THE IN VITRO AND IN VIVO EFFICACY OF CLOTRIMAZOLE OINTMENT

Bulletin of Pharmaceutical Sciences Assiut University
Article 9, Volume 14, Issue 1, 1991, Page 82-94  XML PDF (685.14 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1991.70377
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Authors
S. A. Ibrahim1; E. Hafez1; S. M. El-Shanawany1; I. S. El-Gibaly1; S. A. Ali2
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Dimethyl sulphoxide (DMSO), linoleic acid (LOA) and propylene glycol (PG) glyceryl monostearate (GMS), dioctyl sodium sulphosuccinate and Brij 35 were tested as enhancers for clotrimazole permeation.
The results revealed that, incorporation of the tested promotors in the oleagenous base increased the in vitro release rate of the drug and also its antimycotic activity against Candida albicans. Contrast results were obtained for the water soluble base.
The amount of clotrimazole determined in rabbit skin, was more pronounced when the additives were incorporated in the water soluble base. The histological studies of rabbit skin, showed variable degrees of penetration and no harmful changes of the skin tissues were observed.
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