IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 10, Volume 14, Issue 1, 1991, Page 95-102 PDF (298.64 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1991.70378 | ||||
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| Authors | ||||
| S. I. Saleh1; S. M. Ahmed1; J. M. Aiache2 | ||||
| 1Department. of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Laboratoire de Biopharmacie, Faculte de.Pharmacie, B.P. 38, 63001 Clermont-ferrand Cedex, France | ||||
| Abstract | ||||
| The interaction between temazepam and b-cyclodextrin (b-CD) or hydroxypropyl b-cyclodextrin (HPb-CD) was studied in aqueous solution. The attempts made to obtain temazepam-cyclodextrin complexes in the solid state through freeze drying or slow evaporation under nitrogen of equimolar solutions of temazepam-CD failed to separate these inclusion compounds. On the other hand, co-grinding of temazepam with b-CD or HPb-CD although showed no evidence of formation of inclusion complexes, yet gave rise to very fast dissolution compared to non-treated temazepam or its physical mixtures with CD. Furthermore, the co-grinding of temazepam with Avicel PH 101 (microcrystalline ,cellulose) improved temazepam dissolution to nearly the same extent as those of b-CD or HPb- CD. | ||||
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