FORMULATION OF RIFAMPICIN SUPPOSITORIES
Sayed, H., Ismail, S., Mohamed, A. (1990). FORMULATION OF RIFAMPICIN SUPPOSITORIES. EKB Journal Management System, 13(1), 97-102. doi: 10.21608/bfsa.1990.70551
H. Abdel-Monem Sayed; S. Ismail; A. A. Mohamed. "FORMULATION OF RIFAMPICIN SUPPOSITORIES". EKB Journal Management System, 13, 1, 1990, 97-102. doi: 10.21608/bfsa.1990.70551
Sayed, H., Ismail, S., Mohamed, A. (1990). 'FORMULATION OF RIFAMPICIN SUPPOSITORIES', EKB Journal Management System, 13(1), pp. 97-102. doi: 10.21608/bfsa.1990.70551
Sayed, H., Ismail, S., Mohamed, A. FORMULATION OF RIFAMPICIN SUPPOSITORIES. EKB Journal Management System, 1990; 13(1): 97-102. doi: 10.21608/bfsa.1990.70551

FORMULATION OF RIFAMPICIN SUPPOSITORIES

Bulletin of Pharmaceutical Sciences Assiut University
Article 11, Volume 13, Issue 1, June 1990, Page 97-102  XML PDF (238.4 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1990.70551
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Authors
H. Abdel-Monem Sayed; S. Ismail; A. A. Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Rifampicin is a powerful bactericidal antitubercular drug. The drug was formulated as suppositories. Witepsol H12 was used as the formulating base. Certain other bases as witepsol H15 and W35 and Massa estarinum B and BC as well as cacao butter replaced witepsol H12. Non-ionic surfactants with different chemical compositions, different HLB values as well as different physical and solubility properties were incorporated into witepsol H12 at 5% concentration, of the tested surfactants were polysorbates. Spans, Myrjs and Brijs. Drug dialysis into saline solution at 37°C was studied through cellophane membrane, of the tested bases. Witepsols gave the highest dialysis rates. Polysorbates proved to be superior among the tested surfactants.
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