SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES
Fadl, T., Youssef, A., Ahmed, A., El-Bitar, H. (1990). SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES. EKB Journal Management System, 13(2), 145-158. doi: 10.21608/bfsa.1990.70559
Tarek A. Fadl; Adel F. Youssef; Abdel-Hamed N. Ahmed; Hussein I. El-Bitar. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES". EKB Journal Management System, 13, 2, 1990, 145-158. doi: 10.21608/bfsa.1990.70559
Fadl, T., Youssef, A., Ahmed, A., El-Bitar, H. (1990). 'SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES', EKB Journal Management System, 13(2), pp. 145-158. doi: 10.21608/bfsa.1990.70559
Fadl, T., Youssef, A., Ahmed, A., El-Bitar, H. SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES. EKB Journal Management System, 1990; 13(2): 145-158. doi: 10.21608/bfsa.1990.70559

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 13, Issue 2, December 1990, Page 145-158  XML PDF (493.11 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1990.70559
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Authors
Tarek A. Fadl1; Adel F. Youssef1; Abdel-Hamed N. Ahmed1; Hussein I. El-Bitar2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Positional isomers of dimethyl pyrazole carboxylic acid derivatives were prepared. Some of these compounds showed variable binding capacities towards Cu (II), Zn (II) and Mg (II). The most active chelators Ig and its isomer IIg showed antidotal and antiinflammatory activities higher than D-penicillamine. Both are more active in dose levels much lesser than their median lethal doses (LD50). 5(3)-Methylpyrazole-3(5)-carboxamide showed significant growth inhibition of R. solani. The other derivatives tested displayed growth stimulating activity rather than growth inhibition of the fungus.
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