EVALUATION OF COMMERCIAL BENZOYL METRONIDAZOLE SUSPENSION | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 3, Volume 13, Issue 2, December 1990, Page 159-168 PDF (349.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1990.70562 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S. A. Ibrahim; S. Shawky Tous; T. H. El-Faham; M. A. Hassan | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Benzoyl metronidazole is available in the Egyptian market as suspension. It was reported that its suspension is physically unstable. Hence, it is aimed in this study to evaluate marketed benzoyl metronidazole suspension. Four batches of benzoyl metronidazole suspension were evaluated for sedimentation volume, drug content, particle length distribution, dissolution rate and bioavailability of the drug. The results revealed significant differences in these parameters between and among the batches of the same brand. The commercial suspensions showed physical and chemical stability along 10 months of aging concerning the preceding parameters, except that the number of the large particles increase by aging. The in-vivo evaluation of two benzoyl metronidazole batches was performed in healthy human volunteers. A direct correlation could exist between the in-vitro dissolution characteristics and the in-vivo parameters. | ||||
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