PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES
Habib, F., Sayed, H., Ismail, S., Gomea, A., Shaker, A. (1990). PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES. EKB Journal Management System, 13(2), 265-280. doi: 10.21608/bfsa.1990.70586
F. S. Habib; H. A. Sayed; S. Ismail; A. A. Gomea; A. Shaker. "PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES". EKB Journal Management System, 13, 2, 1990, 265-280. doi: 10.21608/bfsa.1990.70586
Habib, F., Sayed, H., Ismail, S., Gomea, A., Shaker, A. (1990). 'PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES', EKB Journal Management System, 13(2), pp. 265-280. doi: 10.21608/bfsa.1990.70586
Habib, F., Sayed, H., Ismail, S., Gomea, A., Shaker, A. PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES. EKB Journal Management System, 1990; 13(2): 265-280. doi: 10.21608/bfsa.1990.70586

PREPARATION AND EVALUATION OF HYDROXYZINE SUPPOSITORIES

Bulletin of Pharmaceutical Sciences Assiut University
Article 12, Volume 13, Issue 2, December 1990, Page 265-280  XML PDF (557.47 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1990.70586
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Authors
F. S. Habib1; H. A. Sayed1; S. Ismail1; A. A. Gomea2; A. Shaker1
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Hydroxyzine is a piperazine derivative recommended for treatment of anxiety. The drug was formulated in suppository forms using different types of fatty, emulsion and water soluble bases. Non ionic surfactants as well as aerosils were used as formulating additives. The drug release from the formulating bases as well as the tranquilizing potency in mice were evaluated. It was found that formulations which afford the higher release rates in the in-vitro study, give also the more pronounced tranquilizing effect in the animal testing.
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