AMELIORATION OF LEAD TOXICITY ON GROWING RABBITS | ||||
| Journal of Animal and Poultry Production | ||||
| Article 1, Volume 4, Issue 1, January 2013, Page 1-15 PDF (890.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jappmu.2013.70994 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Kh. M. Abd El-Latif1; K. M. Elmeleigy2; Manal A. Atwa2; M. A. Atwa2 | ||||
| 1Specialized Hospital, Ain Shams University | ||||
| 2Regional Center for Food and Feed, Agric. Res. Center, Ministry of Agric., Giza, Egypt. | ||||
| Abstract | ||||
| The aim of the present study was to investigate the effect of the administration of vitamin C, clay, methionine and D-penicillamine against lead-induced toxicity. Rabbit groups fed diets contaminated with 200 mg lead/kg diet recorded the lowest final live body weight, weight gain and feed intake by 9.48, 13.03 and 10.57%, respectively when compared to the healthy control group, on the other hand, feed conversion ratio was impaired by 2.83%. Feed cost, return from body gain and final margin were decreased in rabbit fed diets contaminated with lead when compared with the control group. Lead ingestion resulted in an increase in plasma AST, urea-N and createnine, while the concentrations of hemoglobin, total protein, albumin, globulin and erythrocytes account were decreased. Daily gain (0-8 weeks) were 53.63, 47.10, 61.32 and 63.16%, respectively in rabbit groups fed diets supplemented with clay, D-penicillamine, vitamin C and DL-methionine when compared with the control group. Rabbit groups fed diets supplemented with vitamin C and DL-methionine recorded the best feed conversion compared with the other experimental groups. Rabbit groups fed diets supplemented with vitamin C and DL-methionine recorded higher return from body gain and final margin than the other experimental groups. Rabbits fed lead-exposed diets and supplemented with clay, D-penicillamine, vitamin C and DL-methionine recorded higher final body weight, daily gain, feed intake, return from body gain and final margin, and the best feed conversion compared with the control group. Administration of clay, D-penicillamine, vitamin C and DL-methionine in combination with lead significantly affected erythrocytes, hemoglobin, plasma total protein, urea-N, createnine and AST concentration. Pre-slaughter weight affected each of significantly carcass, carcass cuts and kidney fat weights. On the other hand carcass weight and carcass components were insignificantly affected with lead toxicity, feed additives and their interactions. Contaminated rabbit diets supplemented with clay, D-penicillamine, vitamin C and DL-methionine significantly (P<0.001) reduced lead residual in rabbits muscle. Lead residual in rabbit muscles fed lead contaminated diet was 1.917 mg/kg body weight, while the lead residual in rabbits fed diets contaminated with lead and supplemented with natural clay, D-penicillamine, vitamin C and DL-methionine were 1.293, 1.603, 1.407 and 1.433 mg/kg body weight, respectively. | ||||
| Keywords | ||||
| lead toxicity; Rabbit; clay; methionine; vitamin c; D-penicillamine; Growth performance; blood components; slaughter traits | ||||
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