DESIGN, FORMULATION AND EVALUATION OF CELECOXIB SOLID DISPERSIONS PREPARED BY THE SOLVENT- EVAPORATION TECHNIQUE | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 4, Volume 47, Issue 1 - Serial Number 47, March 2013, Page 36-53 PDF (439.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2013.7107 | ||||
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| Author | ||||
| Yasmin Mortagi | ||||
| Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Industries, Sinai University, El-Arish, North Sinai, Egypt. | ||||
| Abstract | ||||
| The aim of the present study was to improve dissolution of poorly water-soluble Celecoxib by solid dispersion technique using water soluble carriers. Solid dispersions of Celecoxib were prepared with different polymers or carriers such as Hydroxy Propyl Beta Cyclodextrin, polyvinylpyrrolidone (PVP K30) and Urea. Solid dispersions were formulated in drug polymer ratio 1:2.5, 1:5, 1:7.5 and 1:10 using solvent evaporation method. The prepared formulae were assayed for drug content, production yield and micromeritics properties. Dissolution profiles were done in water containing 1% sodium lauryl sulphate and the in-vitro release was ranked according to the % drug released after 60 and 120 minutes. The results indicated that all of the formulated solid dispersions displayed better dissolution profiles as compared to the pure drug. Formula containing drug to HP-β-CD (1:10) was ranked first and gave the best results out of the 12 solid dispersion formulae prepared. | ||||
| Keywords | ||||
| Celecoxib; Solid dispersion; dissolution enhancement; solvent evaporation | ||||
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