IN-VITRO AND IN-VIVO STUDIES ON OPHTHALMIC PREPARATIONS OF XYLOCAINE HYDROCHLORIDE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 4, Volume 12, Issue 1, June 1989, Page 68-89 PDF (668.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1989.71456 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S. Ismail1; A. A. Mohamed1; S. A. Hasan2 | ||||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A number of both hydrophilic and lipophilic surface active agents was employed for preparing simple o/w and multiple w/o/w emulsion systems. The dynamic dialyses 06 xylocaine HCl from its aqueous, micellar solutions and o/w as well as w/o/w emulsion system were studied. The transfer of xylocaine HCl across standard cellophane membrane was fund to follow the diffusion system were controlled mechanism. The data revealed that, the nature of surfactant and emulsion type had a significant role in diffusion of the drug molecules. Generally, the release pattern of the drug from micellar solution or emulsion systems was less than that of the control. In a blind-controlled clinical study, four coded w/o/w and two coded o/w emulsions of 2.5% xylocaine HCl were compared with an aqueous solution of the drug at the same concentration. The longest mean of surface anaesthetic duration, 9,8, minutes was attained with w/o/w emulsion formed of span 60 as a lipophilic emulsifier and Myrj 52 as a hydrophilic one. The clinical application of emulsion formulations in human eyes was found to prolong the mean anaesthetic duration, decrease the eye irritation and improve the performance of the needed clinical manoeuvres. | ||||
|
Statistics Article View: 78 PDF Download: 118 |
||||
