CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES
Safwat, S., El-Monem, H., Moustafa, E. (1989). CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES. EKB Journal Management System, 12(1), 136-151. doi: 10.21608/bfsa.1989.71462
S. M. Safwat; H. A. El-Monem; E. Moustafa. "CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES". EKB Journal Management System, 12, 1, 1989, 136-151. doi: 10.21608/bfsa.1989.71462
Safwat, S., El-Monem, H., Moustafa, E. (1989). 'CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES', EKB Journal Management System, 12(1), pp. 136-151. doi: 10.21608/bfsa.1989.71462
Safwat, S., El-Monem, H., Moustafa, E. CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES. EKB Journal Management System, 1989; 12(1): 136-151. doi: 10.21608/bfsa.1989.71462

CORRELATION BETWEEN GASTRIC IRRITANCY AND BIOAVAILABILITY OF INDOMETHACIN MICROSPHERES

Bulletin of Pharmaceutical Sciences Assiut University
Article 9, Volume 12, Issue 1, June 1989, Page 136-151  XML PDF (566.12 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1989.71462
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Authors
S. M. Safwat1; H. A. El-Monem1; E. Moustafa2
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Indomethacin microspheres were prepared by an emulsion solvent evaporation method. Ethylcellulose was used as the matrix material at 1:1 drug/polymer ratio. The prepared microspheres was tested for drug content, dissolution characteristics, anti-inflammatory effect in rats and for their possible gastric effect in rabbits .A controlled release pattern of the medicament was found to be existed from the prepared microspheres. The prepared microspheres gave an anti-inflammatory effect in rats as that produced by the intact medicament. Histological examination of rabbit's stomach proved the superiority of the tested microsphere over the intact drug.
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