Histological and hormonal analytical studies for the effect of estrogen and testosterone replacement on temporomandibular joint of gonadectomized rats | ||||
| Al-Azhar Journal of Dental Science | ||||
| Article 3, Volume 21, Issue 3, July 2018, Page 209-219 PDF (1.77 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajdsm.2018.71524 | ||||
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| Authors | ||||
| Hani S* 1; Ismail A* 2; Helal A3 | ||||
| 1Professor of Oral Histology and Oral Pathology, Oral Biology Department, Faculty of Dental Medicine Boys, Al-Azhar University, Cairo | ||||
| 2Assistant Professor of Oral Histology, Oral Biology Department, Faculty of Dental Medicine Boys, Al-Azhar University, Assiut | ||||
| 3Demonstrator of Oral Histology Oral Biology Department Faculty of Dental Medicine Boys, Al-Azhar University, Assiut | ||||
| Abstract | ||||
| In this study, 42 male and female Sprague-Dawley rats were used and were divided into five groups including: the control group I involved 14 male and female rats, seven rats each, group II; involved 14 female rats subjected to ovariectomy, group III; involved 14 male rats subjected to testectomy. The group IV; involved 7 of the ovariectomized female rats were injected with estrogen replacement therapy while, the remaining 7 ovariectomized rats served as control. The group V; involved 7 of the testectomized male rats were injected with testosterone replacement therapy, while the other 7 testectomized rats served as control. The surgical interference of gonadectomy was performed under anesthesia and the ovaries of animals in group II were surgically accessed via lateral approach, while the testes of animals in group III were surgically accessed through the lower abdomen. The hormonal injection was performed after 50 days from surgery. The animals of group IV, were injected with estrogen depot intramuscularly with dose of 0.5 mg/kg body weight every 7 days for 4 weeks. The animals of group V, were injected with testosterone depot intramuscularly with dose of 20 mg/kg body weight every 7 days for 4 weeks. Development of lymphoid follicles in synovial membrane showed in ovariectomized rats and in testectomized rats showed proliferation of synovial villi with their invasion by numerous vascular sinusoids, fat cells or lipid-filled macrophages to synovial subintima and the posterior band of articular disc and not improvement in replacement therapy groups and the effect of decreased level of the testosterone on TMJ was more than the estrogen and there is not considerable improvement of TMJ was observed when the animals were treated with hormone replacement therapy. | ||||
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