UTILITY OF SOME SULPHA DRUGS IN SYNTHESIS OF NEW BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS : SYNTHESIS AND ANTICANCER ACTIVITY OF SOME NOVEL THIOSEMICARBAZIDE DERIVATIVES | ||||
| Al-Azhar Bulletin of Science | ||||
| Article 4, Volume 22, Issue 1-A, June 2011, Page 57-68 PDF (145.75 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/absb.2011.7175 | ||||
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| Authors | ||||
| E. M. AHMED* ; N. M. TAHA; N. M. NADY | ||||
| Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| N-(4-(N-(2,6-dimethoxypyrimidin-4-yl)sulfamoyl)phenyl) hydrazine carbothioamide novel thiosemicarbazide (3) was used as starting material for synthesis of some novel Diacetyl hydrazine-carbothioamide (4), 1,3,4-Thiadiazol (7), 1,2-bis(carbothioamide) (9), 3,5-di-oxopyrazolidine (10), oxo-4,5-dihydropyrazole (11), 3,4-dihy-drophthalazine (15) and 3,6-dioxopiperazine (16).Where we found that, 1,2-bis(carbothioamide) (5), 1,2,4-triazole (6), carbamothioyl formohydrazonate (8) have anticancer activity of drug (s) using (E.A.C). | ||||
| Keywords | ||||
| SULPHA DRUGS; THIOSEMICARBAZIDE DERIVATIVES | ||||
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