UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.
MAHMOUD, F., TAHA, N., EL-SHARIEF, A., AHMED, E. (2011). UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.. EKB Journal Management System, 22(Issue 1-A), 163-186. doi: 10.21608/absb.2011.7187
F. F. MAHMOUD; N. M. TAHA; A. M. EL-SHARIEF; E. M. AHMED. "UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.". EKB Journal Management System, 22, Issue 1-A, 2011, 163-186. doi: 10.21608/absb.2011.7187
MAHMOUD, F., TAHA, N., EL-SHARIEF, A., AHMED, E. (2011). 'UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.', EKB Journal Management System, 22(Issue 1-A), pp. 163-186. doi: 10.21608/absb.2011.7187
MAHMOUD, F., TAHA, N., EL-SHARIEF, A., AHMED, E. UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.. EKB Journal Management System, 2011; 22(Issue 1-A): 163-186. doi: 10.21608/absb.2011.7187

UTILITIES OF CYANOTHIOFORMAMIDES AND IMIDAZOLIDINEIMINO-THIONES IN THE SYNTHESIS OF NEW TYPES OF OXADIAZOLE, TRIAZOLTHIONE, BENZOTHIAZOLOQUINAZOLINONE, PYRROLO[2,3-B] PYRROLE AND IMIDAZOTRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST.

Al-Azhar Bulletin of Science
Article 12, Volume 22, Issue 1-A, June 2011, Page 163-186  XML PDF (354.85 K)
Document Type: Original Article
DOI: 10.21608/absb.2011.7187
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Authors
F. F. MAHMOUD* 1; N. M. TAHA1; A. M. EL-SHARIEF2; E. M. AHMED1
1Chemistry Department, Faculty of Science, Al-Azhar University (for Girls), Cairo, Egypt
2Chemistry Department, Faculty of Science, Al-Azhar University (for Boys), Cairo, Egypt
Abstract
Cyanothioformamides were reacted with benzoyl hydrazine, acetyl hydrazine and anthranilic acid to afford oxadiazole (4), triazolthione (5) and benzothiazoloquinazolinone derivatives (6) respectively. They also reacted with thiocarbohydrazide, semicarbazide, thiosemicarbazide and active methylene compounds to produce 3-hydrazino-1,2-,4-triazol-5-thione (8), thiocarbamoylsemicarbazide (9), triazolidinedithione (10). Treatment of imidazolidine iminothiones with different nucleophilic reagents gave imidazotriazines besides other imidazolidine derivatives. Some of the newly synthestized derivatives were screened for antibacterial and antifungal activity and showed prononced antimicrobial activity.
Keywords
CYANOTHIOFORMAMIDES; IMIDAZOLIDINEIMINO-THIONES; Oxadiazole; TRIAZOLTHIONE
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