Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines
Bollikolla, H., g, R., b, S., m, S. (2020). Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines. EKB Journal Management System, 63(8), 2813-2825. doi: 10.21608/ejchem.2019.16652.2014
HARI BABU Bollikolla; Ravi Kumar g; s n murthy b; Santha Kumari m. "Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines". EKB Journal Management System, 63, 8, 2020, 2813-2825. doi: 10.21608/ejchem.2019.16652.2014
Bollikolla, H., g, R., b, S., m, S. (2020). 'Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines', EKB Journal Management System, 63(8), pp. 2813-2825. doi: 10.21608/ejchem.2019.16652.2014
Bollikolla, H., g, R., b, S., m, S. Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines. EKB Journal Management System, 2020; 63(8): 2813-2825. doi: 10.21608/ejchem.2019.16652.2014

Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines

Egyptian Journal of Chemistry
Article 2, Volume 63, Issue 8, August 2020, Pages 2813-2825    PDF (1.07 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.16652.2014
Authors
HARI BABU Bollikolla* 1; Ravi Kumar g2; s n murthy b3; Santha Kumari m4
1DEPT. OF CHEMISTRY, ACHARYA NAGARJUNA UNIVERSITY, NNAGAR,AP-INDIA
2Department of Chemistry, Government Degree College, Husnabad-505467, Telangana, India.
3Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India
4Department of Chemistry, Government Degree College for Women (A), Srikakulam-532001, Andhra Pradesh, India
Abstract
A series of 16 new (±) -1-(4-(3-fluorobenzyloxy) pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives were synthesized from 2,5-dihydro-1H-pyrrole. Sixteen compounds are well characterized by their 1H NMR, 13C NMR and mass spectral data. Anticancer activities of these compounds were tested against HCT 116, MDA-MB231, Mia-PaCa2 cancer cell lines. Among these series of compounds, 8b exhibited highest activity with IC50 of 42.5 µg/ mL against MDA-MB231 cell line. The compound 8o and 8n showed moderate activity with IC50 of 64.3 µg/ mL and 68.4 µg/ mL against HCT -116 and Mia-PaCa2 cancer cell lines respectively.
Keywords
1; 2; 3-Triazole; Anticancer; MDA-MB231; HCT 116; Mia-PaCa2
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