Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines | ||||
Egyptian Journal of Chemistry | ||||
Article 2, Volume 63, Issue 8, August 2020, Page 2813-2825 PDF (1.07 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2019.16652.2014 | ||||
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Authors | ||||
HARI BABU Bollikolla 1; Ravi Kumar g2; s n murthy b3; Santha Kumari m4 | ||||
1DEPT. OF CHEMISTRY, ACHARYA NAGARJUNA UNIVERSITY, NNAGAR,AP-INDIA | ||||
2Department of Chemistry, Government Degree College, Husnabad-505467, Telangana, India. | ||||
3Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India | ||||
4Department of Chemistry, Government Degree College for Women (A), Srikakulam-532001, Andhra Pradesh, India | ||||
Abstract | ||||
A series of 16 new (±) -1-(4-(3-fluorobenzyloxy) pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives were synthesized from 2,5-dihydro-1H-pyrrole. Sixteen compounds are well characterized by their 1H NMR, 13C NMR and mass spectral data. Anticancer activities of these compounds were tested against HCT 116, MDA-MB231, Mia-PaCa2 cancer cell lines. Among these series of compounds, 8b exhibited highest activity with IC50 of 42.5 µg/ mL against MDA-MB231 cell line. The compound 8o and 8n showed moderate activity with IC50 of 64.3 µg/ mL and 68.4 µg/ mL against HCT -116 and Mia-PaCa2 cancer cell lines respectively. | ||||
Keywords | ||||
1; 2; 3-Triazole; Anticancer; MDA-MB231; HCT 116; Mia-PaCa2 | ||||
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