INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS
Abdel Rahman, A., Aboutaleb, A., Mulley, B., Ahmed, S. (1989). INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS. EKB Journal Management System, 12(2), 175-194. doi: 10.21608/bfsa.1989.72053
A. A. Abdel Rahman; A. E. Aboutaleb; B. A. Mulley; S. M. Ahmed. "INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS". EKB Journal Management System, 12, 2, 1989, 175-194. doi: 10.21608/bfsa.1989.72053
Abdel Rahman, A., Aboutaleb, A., Mulley, B., Ahmed, S. (1989). 'INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS', EKB Journal Management System, 12(2), pp. 175-194. doi: 10.21608/bfsa.1989.72053
Abdel Rahman, A., Aboutaleb, A., Mulley, B., Ahmed, S. INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS. EKB Journal Management System, 1989; 12(2): 175-194. doi: 10.21608/bfsa.1989.72053

INTERACTION OF TEMAZEPAM WITH HYDROPHILIC MACROMOLECULES VI- PREPARATION, DISSOLUTION CHARACTERISTICS AND AGEING OF TEMAZEPAM SOLID DISPERSIONS

Bulletin of Pharmaceutical Sciences Assiut University
Article 1, Volume 12, Issue 2, December 1989, Page 175-194  XML PDF (786.91 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1989.72053
View on SCiNiTO View on SCiNiTO
Authors
A. A. Abdel Rahman1; A. E. Aboutaleb1; B. A. Mulley2; S. M. Ahmed1
1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2School of Pharmacy, Bradford University, England
Abstract
Temazepam solid dispersions were prepared using the solvent and the fusion methods with certain hydrophilic carriers including polyethylene glycol 6000 (PEG 6000),Murj 52, polyvinyl pyrrolidone 10000 (PVP 10000), and polyvinyl pyrrolidone 40000 (PVP 40000).
It was found that the solvent method is preferable than the fusion method.
          Thin layer chromatographic investigations revealed that three was no chemical degradation of the drug or the carriers through processing.
          Infrared analysis revealed that there was no evidence for complexation between temazepam and the investigated carriers nor decomposition of the drug.
          Differential scanning calorimetery (DSC) investigations illustrated that the drug present in the coprecipitates in the amorphous form in the fresh samples as well as the aged-ones. HPLC in the aged samples proved no drug degradation.
Statistics
Article View: 71
PDF Download: 126